A High-Performance, Low Power Research Hearing Aid featuring a High-Level Programmable Custom 22nm FDSOI SoC.

With advances in algorithmic hearing aid research, the need for high-level programmable, behind-the-ear (BTE) wearable and low-power research platforms is emerging. These can be used to test new algorithms in real-world scenarios. Although various groups are developing different portable solutions, they are not in a BTE form factor. For this reason, the devices must be worn around the neck or somewhere on the body, which causes limited mobility and can lead to inaccurate research results. Therefore, this work presents a fully integrated and functional hearing aid research platform that weighs only 5 grams and can be worn behind the ear. The platform is high-level programmable, features wireless technologies such as near-field magnetic induction (NFMI) and Bluetooth Low Energy (BLE), and integrates two micro-electro-mechanical systems (MEMS) microphones and an external speaker. The audio processor of the system is based on a new custom, low-power 22nm mixed-signal system on chip (SoC). Different real-world use cases, like a dynamic compressor, are used to evaluate the platform. With a total power consumption of 47 mW, the rechargeable device achieves a run-time of six hours. When the wireless interfaces are turned off, the power consumption drops to 31 mW, and the run-time increases to nine hours.Clinical relevance-The proposed research hearing aid demonstration platform can be used portable and outside the clinical setting for algorithmic research. With its behind-the-ear form factor and rechargeable battery, studies can be conducted for several hours without restricting patient movement in real-world scenarios.

Predictive accuracy of CNN for cortical oscillatory activity in an acute rat model of parkinsonism.

In neurological and neuropsychiatric disorders neuronal oscillatory activity between basal ganglia and cortical circuits are altered, which may be useful as biomarker for adaptive deep brain stimulation. We investigated whether changes in the spectral power of oscillatory activity in the motor cortex (MCtx) and the sensorimotor cortex (SMCtx) of rats after injection of the dopamine (DA) receptor antagonist haloperidol (HALO) would be similar to those observed in Parkinson disease. Thereafter, we tested whether a convolutional neural network (CNN) model would identify brain signal alterations in this acute model of parkinsonism. A sixteen channel surface micro-electrocorticogram (ECoG) recording array was placed under the dura above the MCtx and SMCtx areas of one hemisphere under general anaesthesia in rats. Seven days after surgery, micro ECoG was recorded in individual free moving rats in three conditions: (1) basal activity, (2) after injection of HALO (0.5 mg/kg), and (3) with additional injection of apomorphine (APO) (1 mg/kg). Furthermore, a CNN-based classification consisting of 23,530 parameters was applied on the raw data. HALO injection decreased oscillatory theta band activity (4-8 Hz) and enhanced beta (12-30 Hz) and gamma (30-100 Hz) in MCtx and SMCtx, which was compensated after APO injection (P ¡ 0.001). Evaluation of classification performance of the CNN model provided accuracy of 92%, sensitivity of 90% and specificity of 93% on one-dimensional signals. The CNN proposed model requires a minimum of sensory hardware and may be integrated into future research on therapeutic devices for Parkinson disease, such as adaptive closed loop stimulation, thus contributing to more efficient way of treatment.

Honey bees increase their foraging performance and frequency of pollen trips through experience.

Honey bee foragers must supply their colony with a balance of pollen and nectar to sustain optimal colony development. Inter-individual behavioural variability among foragers is observed in terms of activity levels and nectar vs. pollen collection, however the causes of such variation are still open questions. Here we explored the relationship between foraging activity and foraging performance in honey bees (Apis mellifera) by using an automated behaviour monitoring system to record mass on departing the hive, trip duration, presence of pollen on the hind legs and mass upon return to the hive, during the lifelong foraging career of individual bees. In our colonies, only a subset of foragers collected pollen, and no bee exclusively foraged for pollen. A minority of very active bees (19% of the foragers) performed 50% of the colony's total foraging trips, contributing to both pollen and nectar collection. Foraging performance (amount and rate of food collection) depended on bees' individual experience (amount of foraging trips completed). We argue that this reveals an important vulnerability for these social bees since environmental stressors that alter the activity and reduce the lifespan of foragers may prevent bees ever achieving maximal performance, thereby seriously compromising the effectiveness of the colony foraging force.

Stress decreases pollen foraging performance in honeybees.

Foraging in honeybees is energetically demanding. Here, we examined whether stressors, which generally increase metabolic demands, can impair foraging performance. A controlled non-pathogenic stressor (immune challenge) resulted in a change in the foraging preferences of bees. It reduced pollen foraging and increased the duration of trips in pollen foragers. Stress also reduced the amount of octopamine in the brain of pollen foragers (a biogenic amine involved in the regulation of foraging and flight behaviour in insects). According to the literature, flight metabolic rate is higher during pollen foraging than during nectar foraging, and nectar gives a higher energetic return relative to the foraging effort when compared with pollen. We thus propose that stress might be particularly detrimental to the performance of pollen foragers, and stressed bees prefer the energy-rich resource of nectar. In conclusion, stress, even at low levels, could have consequences for bee foraging behaviour and thereby the nutritional balance of the colony.

Influence of implant length and bone defect situation on primary stability after distal femoral replacement in vitro.

BACKGROUND: Aseptic loosening is the major reason for failure of distal femoral replacement using current modular megaprostheses. Although the same stems are used for proximal and distal replacement, survival rates in clinical studies with distal reconstruction were lower within the same system compared to proximal reconstruction. We analyzed whether primary stability as presupposition for long-term fixation can be achieved with a current tapered stem design. Additionally, we hypothesized that stem length affects primary stability depending on bone defect situations. METHODS: A modular tumor system (Megasystem-C®, Link GmbH, Hamburg, Germany) with two different tapered stems (100 and 160mm) was implanted in eight Sawbones® in two consecutively created defect situations (10 and 20cm proximal to knee joint level). Primary rotational stability was investigated by measuring relative micromotions between implant and bone to identify the main fixation areas and to characterize the fixation pattern. RESULTS: The fixation differed between the two stem lengths and with respect to both defect situations; however in each case the main fixation area was located at or close to the femoral isthmus. Highest relative micromotions were measured with the 160-mm stem at the distal end within small bone defects and at the proximal end when defects were increased. CONCLUSIONS: The analyzed design seemed to create sufficient primary stability along the main fixation areas of the implant. Based on these results and with respect to oncologic or potential revision situations, we suggest the use of the shorter stem to be more favorable in case of primary implant fixation.

Inter-individual variability in the foraging behaviour of traplining bumblebees.

Workers of social insects, such as bees, ants and wasps, show some degree of inter-individual variability in decision-making, learning and memory. Whether these natural cognitive differences translate into distinct adaptive behavioural strategies is virtually unknown. Here we examined variability in the movement patterns of bumblebee foragers establishing routes between artificial flowers. We recorded all flower visitation sequences performed by 29 bees tested for 20 consecutive foraging bouts in three experimental arrays, each characterised by a unique spatial configuration of artificial flowers and three-dimensional landmarks. All bees started to develop efficient routes as they accumulated foraging experience in each array, and showed consistent inter-individual differences in their levels of route fidelity and foraging performance, as measured by travel speed and the frequency of revisits to flowers. While the tendency of bees to repeat the same route was influenced by their colony origin, foraging performance was correlated to body size. The largest foragers travelled faster and made less revisits to empty flowers. We discuss the possible adaptive value of such inter-individual variability within the forager caste for optimisation of colony-level foraging performances in social pollinators.

Why Bees Are So Vulnerable to Environmental Stressors.

Bee populations are declining in the industrialized world, raising concerns for the sustainable pollination of crops. Pesticides, pollutants, parasites, diseases, and malnutrition have all been linked to this problem. We consider here neurobiological, ecological, and evolutionary reasons why bees are particularly vulnerable to these environmental stressors. Central-place foraging on flowers demands advanced capacities of learning, memory, and navigation. However, even at low intensity levels, many stressors damage the bee brain, disrupting key cognitive functions needed for effective foraging, with dramatic consequences for brood development and colony survival. We discuss how understanding the relationships between the actions of stressors on the nervous system, individual cognitive impairments, and colony decline can inform constructive interventions to sustain bee populations.

The neonicotinoid clothianidin interferes with navigation of the solitary bee Osmia cornuta in a laboratory test.

Pollinating insects provide a vital ecosystem service to crops and wild plants. Exposure to low doses of neonicotinoid insecticides has sub-lethal effects on social pollinators such as bumblebees and honeybees, disturbing their navigation and interfering with their development. Solitary Hymenoptera are also very important ecosystem service providers, but the sub-lethal effects of neonicotinoids have not yet been studied well in those animals. We analyzed the ability of walking Osmia to remember a feeding place in a small environment and found that Osmia remembers the feeding place well after 4 days of training. Uptake of field-realistic amounts of the neonicotinoid clothianidin (0.76 ng per bee) altered the animals' sensory responses to the visual environment and interfered with the retrieval of navigational memory. We conclude that the neonicotinoid clothianidin compromises visual guidance and the use of navigational memory in the solitary bee Osmia cornuta.

Increase in carbon accumulation in a boreal peatland following a period of wetter climate and long-term decrease in nitrogen deposition.

Rates of peat growth and carbon (C) accumulation in a Sphagnum-dominated boreal peatland in south-east Norway were compared over two time periods each 17 yr long, that is, an earlier period from 1978 to 1995 and a recent period from 1995 to 2012. Our research was based on 109 peat cores. By using exactly the same study area and sampling protocols to obtain data for the two time periods, we were able to obtain a clear picture of the spatio-temporal patterns of peat accumulation. We show that peat growth and C accumulation were significantly higher in the recent than in the earlier time period. Interestingly, nitrogen (N) deposition was lower in the recent than in the earlier time period, while precipitation increased in the recent time period. Temperatures did not show any consistent trends over the time periods. Although our data do not allow assessment of the relative importance of declining N deposition vs increasing precipitation as drivers of peat accumulation, our results suggest that peatland C sequestration is not significantly inhibited by N pollution at current precipitation and N deposition levels.